VOLUME 3 - NUMBER 3 - 2021

Effect of high-risk human papillomavirus infection on adverse obstetric outcomes


  • Yaned Lourdes Santana Mateo, Alejandra Santana Suárez, Sonia Carballo Rastrilla, Norberto Medina Ramos, Miguel Andújar Sánchez, Emergui Zrihen Yonit, Alicia Martin-Martinez
  • Original paper, 146-150
  • Full text PDF
  • Background: Human papillomavirus (HPV) infection has been associated with an increased risk of preterm birth and severe preeclampsia. We analyzed the prevalence and association of high-risk HPV infection in pregnant women with adverse obstetric outcomes.

    Methods: In this retrospective case-control study, conducted between 1 January and 30 June 2016, we included 349 pregnant women with singleton pregnancies who underwent HPV testing and completed a postpartum questionnaire.

    Results: A total of 297 women had a negative HPV test (84.8%). The prevalence of high-risk HPV genotypes was 15.2%. Mean age was 30.95 years, 28.75 in the HPV-positive group and 31.34 in the HPV-negative group (P = 0.003). In the HPV-positive group, the average age at sexual debut was lower (P = 0.03) and this group also had more smokers (P = 0.044). Lower birth weight (3022 g vs 3212 g; P = 0.034) and more admissions to the neonatal intensive care unit (7.5% vs 2.4%; P = 0.091) were also observed in this group.

    Conclusions: HPV could contribute to the development of threatened premature labour but does not appear to be related to premature rupture of the membranes or hypertensive disorders of pregnancy. Prospective studies with larger sample sizes are needed to this possible relationship.

  • KEY WORDS: Human papillomavirus, prevalence, pregnancy outcomes, preeclampsia, preterm birth, premature rupture of foetal membranes.